PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease

Biomechanical stress and cytoskeletal remodeling are key determinants of cellular homeostasis and tissue responses to mechanical stimuli and injury. Here we document the increased activity of gelsolin, an actin filament severing and capping protein, in failing human hearts. Deletion of gelsolin prev...

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Detalles Bibliográficos
Autores principales: Patel, Vaibhav B., Zhabyeyev, Pavel, Chen, Xueyi, Wang, Faqi, Paul, Manish, Fan, Dong, McLean, Brent A., Basu, Ratnadeep, Zhang, Pu, Shah, Saumya, Dawson, John F., Pyle, W. Glen, Hazra, Mousumi, Kassiri, Zamaneh, Hazra, Saugata, Vanhaesebroeck, Bart, McCulloch, Christopher A., Oudit, Gavin Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300608/
https://www.ncbi.nlm.nih.gov/pubmed/30568254
http://dx.doi.org/10.1038/s41467-018-07812-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300608/
https://www.ncbi.nlm.nih.gov/pubmed/30568254
http://dx.doi.org/10.1038/s41467-018-07812-8

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