Cytotoxic and pro-apoptotic action of MjTX-I, a phospholipase A2 isolated from Bothrops moojeni snake venom, towards leukemic cells

BACKGROUND: Chronic myeloid leukemia (CML) is a BCR-ABL1(+) myeloproliferative neoplasm marked by increased myeloproliferation and presence of leukemic cells resistant to apoptosis. The current first-line therapy for CML is administration of the tyrosine kinase inhibitors imatinib mesylate, dasatini...

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Detalles Bibliográficos
Autores principales: Benati, Rogério Bodini, Costa, Tássia Rafaela, Cacemiro, Maira da Costa, Sampaio, Suely Vilela, de Castro, Fabíola Attié, Burin, Sandra Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300906/
https://www.ncbi.nlm.nih.gov/pubmed/30598659
http://dx.doi.org/10.1186/s40409-018-0180-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300906/
https://www.ncbi.nlm.nih.gov/pubmed/30598659
http://dx.doi.org/10.1186/s40409-018-0180-9

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