NLRC4 suppresses IL-17A-mediated neutrophil-dependent host defense through upregulation of IL-18 and induction of necroptosis during Gram-positive pneumonia

Gram-positive pathogens, including Staphylococcus aureus cause necrotizing pneumonia. The central feature of S. aureus pneumonia is toxin-induced necroptosis of immune and resident cells, which impedes host defense. However, the role of the NLRC4 in the lung following S. aureus infection remains elu...

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Detalles Bibliográficos
Autores principales: Paudel, Sagar, Ghimire, Laxman, Jin, Liliang, Baral, Pankaj, Cai, Shanshan, Jeyaseelan, Samithamby
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301100/
https://www.ncbi.nlm.nih.gov/pubmed/30279514
http://dx.doi.org/10.1038/s41385-018-0088-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301100/
https://www.ncbi.nlm.nih.gov/pubmed/30279514
http://dx.doi.org/10.1038/s41385-018-0088-2

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