MGMT is down-regulated independently of promoter DNA methylation in rats with all-trans retinoic acid-induced spina bifida aperta

O6-methylguanine DNA methyltransferase (MGMT), a DNA repair enzyme, has been reported in some congenital malformations, but it is less frequently reported in neural tube defects. This study investigated MGMT mRNA expression and methylation levels in the early embryo and in different embryonic stages...

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Detalles Bibliográficos
Autores principales: Zhang, He-Nan, Guo, Yi, Ma, Wei, Xue, Jia, Wang, Wei-Lin, Yuan, Zheng-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301176/
https://www.ncbi.nlm.nih.gov/pubmed/30531021
http://dx.doi.org/10.4103/1673-5374.244799