Pharmacokinetic interaction between mitotane and etoposide in adrenal carcinoma: a pilot study

BACKGROUND: The combination of mitotane and platinum-etoposide chemotherapy is a front-line treatment in metastatic adrenocortical carcinoma (ACC), although this regimen shows limited efficacy. Pharmacokinetic drug–drug interaction between mitotane, a strong CYP3A4 inducer, and etoposide, which is a...

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Detalles Bibliográficos
Autores principales: Jouinot, Anne, Royer, Bernard, Chatelut, Etienne, Moeung, Sotheara, Assié, Guillaume, Thomas-Schoemann, Audrey, Bertherat, Jérôme, Goldwasser, François, Blanchet, Benoit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301193/
https://www.ncbi.nlm.nih.gov/pubmed/30533000
http://dx.doi.org/10.1530/EC-18-0428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301193/
https://www.ncbi.nlm.nih.gov/pubmed/30533000
http://dx.doi.org/10.1530/EC-18-0428

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