Critical evaluation of linear regression models for cell-subtype specific methylation signal from mixed blood cell DNA

Epigenome-wide association studies seek to identify DNA methylation sites associated with clinical outcomes. Difference in observed methylation between specific cell-subtypes is often of interest; however, available samples often comprise a mixture of cells. To date, cell-subtype estimates have been...

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Detalles Bibliográficos
Autores principales: Kennedy, Daniel W., White, Nicole M., Benton, Miles C., Fox, Andrew, Scott, Rodney J., Griffiths, Lyn R., Mengersen, Kerrie, Lea, Rodney A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301777/
https://www.ncbi.nlm.nih.gov/pubmed/30571772
http://dx.doi.org/10.1371/journal.pone.0208915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301777/
https://www.ncbi.nlm.nih.gov/pubmed/30571772
http://dx.doi.org/10.1371/journal.pone.0208915

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