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Critical evaluation of linear regression models for cell-subtype specific methylation signal from mixed blood cell DNA
Epigenome-wide association studies seek to identify DNA methylation sites associated with clinical outcomes. Difference in observed methylation between specific cell-subtypes is often of interest; however, available samples often comprise a mixture of cells. To date, cell-subtype estimates have been...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301777/ https://www.ncbi.nlm.nih.gov/pubmed/30571772 http://dx.doi.org/10.1371/journal.pone.0208915 |