Intracellular albumin overload elicits endoplasmic reticulum stress and PKC-delta/p38 MAPK pathway activation to induce podocyte apoptosis

Podocyte injury is closely related to proteinuria and the progression of chronic kidney disease (CKD). Currently, there is no conclusive understanding about the mechanisms involved in albumin overload and podocyte apoptosis response. In this study, we sought to explore the ways by which intracellula...

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Detalles Bibliográficos
Autores principales: Gonçalves, Guilherme Lopes, Costa-Pessoa, Juliana Martins, Thieme, Karina, Lins, Bruna Bezerra, Oliveira-Souza, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301950/
https://www.ncbi.nlm.nih.gov/pubmed/30573754
http://dx.doi.org/10.1038/s41598-018-36933-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301950/
https://www.ncbi.nlm.nih.gov/pubmed/30573754
http://dx.doi.org/10.1038/s41598-018-36933-9

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