Dissection of genetic variation and evidence for pleiotropy in male pattern baldness

Male pattern baldness (MPB) is a sex-limited, age-related, complex trait. We study MPB genetics in 205,327 European males from the UK Biobank. Here we show that MPB is strongly heritable and polygenic, with pedigree-heritability of 0.62 (SE = 0.03) estimated from close relatives, and SNP-heritabilit...

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Detalles Bibliográficos
Autores principales: Yap, Chloe X., Sidorenko, Julia, Wu, Yang, Kemper, Kathryn E., Yang, Jian, Wray, Naomi R., Robinson, Matthew R., Visscher, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302097/
https://www.ncbi.nlm.nih.gov/pubmed/30573740
http://dx.doi.org/10.1038/s41467-018-07862-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302097/
https://www.ncbi.nlm.nih.gov/pubmed/30573740
http://dx.doi.org/10.1038/s41467-018-07862-y

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