IP(3) Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca(2+) to Lysosomes

Inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) allow extracellular stimuli to redistribute Ca(2+) from the ER to cytosol or other organelles. We show, using small interfering RNA (siRNA) and vacuolar H(+)-ATPase (V-ATPase) inhibitors, that lysosomes sequester Ca(2+) released by all IP(3)R...

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Detalles Bibliográficos
Autores principales: Atakpa, Peace, Thillaiappan, Nagendra Babu, Mataragka, Stefania, Prole, David L., Taylor, Colin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302550/
https://www.ncbi.nlm.nih.gov/pubmed/30540949
http://dx.doi.org/10.1016/j.celrep.2018.11.064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302550/
https://www.ncbi.nlm.nih.gov/pubmed/30540949
http://dx.doi.org/10.1016/j.celrep.2018.11.064

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