Cargando…
Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential
We characterized 55 influenza A(H9N2) viruses isolated in Pakistan during 2014–2016 and found that the hemagglutinin gene is of the G1 lineage and that internal genes have differentiated into a variety of novel genotypes. Some isolates had up to 4-fold reduction in hemagglutination inhibition titers...
Autores principales: | Sealy, Joshua E., Yaqub, Tahir, Peacock, Thomas P., Chang, Pengxiang, Ermetal, Burcu, Clements, Anabel, Sadeyen, Jean-Remy, Mehboob, Arslan, Shelton, Holly, Bryant, Juliet E., Daniels, Rod S., McCauley, John W., Iqbal, Munir |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302589/ https://www.ncbi.nlm.nih.gov/pubmed/30561311 http://dx.doi.org/10.3201/eid2501.180616 |
Ejemplares similares
-
Immune Escape Variants of H9N2 Influenza Viruses Containing Deletions at the Hemagglutinin Receptor Binding Site Retain Fitness In Vivo and Display Enhanced Zoonotic Characteristics
por: Peacock, Thomas P., et al.
Publicado: (2017) -
The Application of NHEJ-CRISPR/Cas9 and Cre-Lox System in the Generation of Bivalent Duck Enteritis Virus Vaccine against Avian Influenza Virus
por: Chang, Pengxiang, et al.
Publicado: (2018) -
Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion
por: Peacock, Thomas P, et al.
Publicado: (2017) -
Immune Escape Adaptive Mutations in the H7N9 Avian Influenza Hemagglutinin Protein Increase Virus Replication Fitness and Decrease Pandemic Potential
por: Chang, Pengxiang, et al.
Publicado: (2020) -
Contribution of Segment 3 to the Acquisition of Virulence in Contemporary H9N2 Avian Influenza Viruses
por: Clements, Anabel L., et al.
Publicado: (2020)