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Improved protein production and codon optimization analyses in Escherichia coli by bicistronic design
Different codon optimization algorithms are available that aim at improving protein production by optimizing translation elongation. In these algorithms, it is generally not considered how the altered protein coding sequence will affect the secondary structure of the corresponding RNA transcript, pa...
Autores principales: | Nieuwkoop, Thijs, Claassens, Nico J., van der Oost, John |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302717/ https://www.ncbi.nlm.nih.gov/pubmed/30484964 http://dx.doi.org/10.1111/1751-7915.13332 |
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