Optimized vinpocetine-loaded vitamin E D-α-tocopherol polyethylene glycol 1000 succinate-alpha lipoic acid micelles as a potential transdermal drug delivery system: in vitro and ex vivo studies

BACKGROUND: Vinpocetine (VNP), a semisynthetic natural product, is used as a vasodilator for cerebrovascular and age-related memory disorders. VNP suffers from low oral bioavailability owing to its low water solubility and extensive first-pass metabolism. This work aimed at utilizing D-α-tocopherol...

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Detalles Bibliográficos
Autores principales: Ahmed, Osama AA, El-Say, Khalid M, Aljaeid, Bader M, Badr-Eldin, Shaimaa M, Ahmed, Tarek A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302827/
https://www.ncbi.nlm.nih.gov/pubmed/30587983
http://dx.doi.org/10.2147/IJN.S187470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302827/
https://www.ncbi.nlm.nih.gov/pubmed/30587983
http://dx.doi.org/10.2147/IJN.S187470

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