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Optimized vinpocetine-loaded vitamin E D-α-tocopherol polyethylene glycol 1000 succinate-alpha lipoic acid micelles as a potential transdermal drug delivery system: in vitro and ex vivo studies

BACKGROUND: Vinpocetine (VNP), a semisynthetic natural product, is used as a vasodilator for cerebrovascular and age-related memory disorders. VNP suffers from low oral bioavailability owing to its low water solubility and extensive first-pass metabolism. This work aimed at utilizing D-α-tocopherol...

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Detalles Bibliográficos
Autores principales:	Ahmed, Osama AA, El-Say, Khalid M, Aljaeid, Bader M, Badr-Eldin, Shaimaa M, Ahmed, Tarek A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302827/ https://www.ncbi.nlm.nih.gov/pubmed/30587983 http://dx.doi.org/10.2147/IJN.S187470

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