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Mitochondrial genome and functional defects in osteosarcoma are associated with their aggressive phenotype

Osteosarcoma (OSA) is an aggressive mesenchymal tumor of the bone that affects children and occurs spontaneously in dogs. Human and canine OSA share similar clinical, biological and genetic features, which make dogs an excellent comparative model to investigate the etiology and pathogenesis of OSA....

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Detalles Bibliográficos
Autores principales: Jackson, Martina, Serada, Nicole, Sheehan, Maura, Srinivasan, Satish, Mason, Nicola, Guha, Manti, Avadhani, Narayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303035/
https://www.ncbi.nlm.nih.gov/pubmed/30576337
http://dx.doi.org/10.1371/journal.pone.0209489