FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer

Changes in cancer cell identity can alter malignant potential and therapeutic response. Loss of the pulmonary lineage specifier NKX2-1 augments the growth of KRAS-driven lung adenocarcinoma and causes pulmonary to gastric transdifferentiation. Here, we show that the transcription factors FoxA1 and F...

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Detalles Bibliográficos
Autores principales: Camolotto, Soledad A, Pattabiraman, Shrivatsav, Mosbruger, Timothy L, Jones, Alex, Belova, Veronika K, Orstad, Grace, Streiff, Mitchell, Salmond, Lydia, Stubben, Chris, Kaestner, Klaus H, Snyder, Eric L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303105/
https://www.ncbi.nlm.nih.gov/pubmed/30475207
http://dx.doi.org/10.7554/eLife.38579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303105/
https://www.ncbi.nlm.nih.gov/pubmed/30475207
http://dx.doi.org/10.7554/eLife.38579

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