Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized (13)C-methylglyoxal

Methylglyoxal is a faulty metabolite. It is a ubiquitous by-product of glucose and amino acid metabolism that spontaneously reacts with proximal amino groups in proteins and nucleic acids, leading to impairment of their function. The glyoxalase pathway evolved early in phylogeny to bring about rapid...

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Detalles Bibliográficos
Autores principales: Shishmarev, Dmitry, Kuchel, Philip W., Pagès, Guilhem, Wright, Alan J., Hesketh, Richard L., Kreis, Felix, Brindle, Kevin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303249/
https://www.ncbi.nlm.nih.gov/pubmed/30588511
http://dx.doi.org/10.1038/s42003-018-0241-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303249/
https://www.ncbi.nlm.nih.gov/pubmed/30588511
http://dx.doi.org/10.1038/s42003-018-0241-1

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