Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism

Phosphoglycerate dehydrogenase (PHGDH) catalyzes the committed step in de novo serine biosynthesis. Paradoxically, PHGDH and serine synthesis are required in the presence of abundant environmental serine even when serine uptake exceeds the requirements for nucleotide synthesis. Here, we establish a...

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Detalles Bibliográficos
Autores principales: Reid, Michael A., Allen, Annamarie E., Liu, Shiyu, Liberti, Maria V., Liu, Pei, Liu, Xiaojing, Dai, Ziwei, Gao, Xia, Wang, Qian, Liu, Ying, Lai, Luhua, Locasale, Jason W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303315/
https://www.ncbi.nlm.nih.gov/pubmed/30575741
http://dx.doi.org/10.1038/s41467-018-07868-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303315/
https://www.ncbi.nlm.nih.gov/pubmed/30575741
http://dx.doi.org/10.1038/s41467-018-07868-6

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