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The H/ACA complex disrupts triplex in hTR precursor to permit processing by RRP6 and PARN
Human telomerase RNA (hTR) is transcribed as a precursor that is then posttranscriptionally modified and processed. A fraction of the transcripts is oligoadenylated by TRAMP and either processed into the mature hTR or degraded by the exosome. Here, we characterize the processing of 3′ extended forms...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303318/ https://www.ncbi.nlm.nih.gov/pubmed/30575725 http://dx.doi.org/10.1038/s41467-018-07822-6 |