Expression of the human antimicrobial peptide β-defensin-1 is repressed by the EGFR-ERK-MYC axis in colonic epithelial cells

The human β-defensin-1 (HBD1) is an antimicrobial peptide constitutively expressed by epithelial cells at mucosal surfaces. In addition to its microbicidal properties, the loss of HBD1 expression in several cancers suggests that it may also have an anti-tumor activity. Here, we investigated the link...

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Detalles Bibliográficos
Autores principales: Bonamy, Clément, Sechet, Emmanuel, Amiot, Aurélien, Alam, Antoine, Mourez, Michael, Fraisse, Laurent, Sansonetti, Philippe J., Sperandio, Brice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303337/
https://www.ncbi.nlm.nih.gov/pubmed/30575780
http://dx.doi.org/10.1038/s41598-018-36387-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303337/
https://www.ncbi.nlm.nih.gov/pubmed/30575780
http://dx.doi.org/10.1038/s41598-018-36387-z

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