Toll-Like Receptor-4 Disruption Suppresses Adipose Tissue Remodeling and Increases Survival in Cancer Cachexia Syndrome

Cancer-induced cachexia, characterized by systemic inflammation, body weight loss, adipose tissue (AT) remodeling and muscle wasting, is a malignant metabolic syndrome with undefined etiology. Here, we show that both genetic ablation and pharmacological inhibition of TLR4 were able to attenuate the...

Descripción completa

Detalles Bibliográficos
Autores principales: Henriques, Felipe, Lopes, Magno A., Franco, Felipe O., Knobl, Pamela, Santos, Kaltinaitis B., Bueno, Luana L., Correa, Victor A., Bedard, Alexander H., Guilherme, Adilson, Birbrair, Alexander, Peres, Sidney B., Farmer, Stephen R., Batista, Miguel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303407/
https://www.ncbi.nlm.nih.gov/pubmed/30575787
http://dx.doi.org/10.1038/s41598-018-36626-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303407/
https://www.ncbi.nlm.nih.gov/pubmed/30575787
http://dx.doi.org/10.1038/s41598-018-36626-3

Ejemplares similares