MTHFR variant is associated with high-dose methotrexate-induced toxicity in the Chinese osteosarcoma patients

BACKGROUND: The role of Methylene tetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in the efficacy and toxicity of MTX-based therapy remains uncertain. Our purpose was to clarify whether these two polymorphisms are associated with the outcome of chemotherapy in a cohort of Chinese o...

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Detalles Bibliográficos
Autores principales: Xu, Leilei, Wang, Lujun, Xue, Bingchuan, Wang, Shoufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303521/
https://www.ncbi.nlm.nih.gov/pubmed/30591868
http://dx.doi.org/10.1016/j.jbo.2018.10.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303521/
https://www.ncbi.nlm.nih.gov/pubmed/30591868
http://dx.doi.org/10.1016/j.jbo.2018.10.002

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