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MTHFR variant is associated with high-dose methotrexate-induced toxicity in the Chinese osteosarcoma patients
BACKGROUND: The role of Methylene tetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in the efficacy and toxicity of MTX-based therapy remains uncertain. Our purpose was to clarify whether these two polymorphisms are associated with the outcome of chemotherapy in a cohort of Chinese o...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303521/ https://www.ncbi.nlm.nih.gov/pubmed/30591868 http://dx.doi.org/10.1016/j.jbo.2018.10.002 |