SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4

BACKGROUND: Epithelial-to-mesenchymal transition (EMT) contributes to the invasion and metastasis of epithelial tumors. Sirtuin 6 (SIRT6), an NAD-dependent deacetylase, is known to promote metastasis of non-small cell lung cancer (NSCLC). METHODS: In this work, we determined the role of SIRT6 in the...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Ziming, Huang, Jia, Shen, Shengping, Ding, Zhenping, Luo, Qingquan, Chen, Zhiwei, Lu, Shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303940/
https://www.ncbi.nlm.nih.gov/pubmed/30577808
http://dx.doi.org/10.1186/s13046-018-0984-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303940/
https://www.ncbi.nlm.nih.gov/pubmed/30577808
http://dx.doi.org/10.1186/s13046-018-0984-z

Ejemplares similares