Blockade of LAG-3 Immune Checkpoint Combined With Therapeutic Vaccination Restore the Function of Tissue-Resident Anti-viral CD8(+) T Cells and Protect Against Recurrent Ocular Herpes Simplex Infection and Disease

Recurrent viral diseases often occur after the viruses evade the hosts' immune system, by inducing exhaustion of antiviral T cells. In the present study, we found that functionally exhausted herpes simplex virus type 1 (HSV-1) -specific CD8(+) T cells, with elevated expression of lymphocyte act...

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Detalles Bibliográficos
Autores principales: Roy, Soumyabrata, Coulon, Pierre-Grégoire, Srivastava, Ruchi, Vahed, Hawa, Kim, Grace J., Walia, Sager S., Yamada, Taikun, Fouladi, Mona A., Ly, Vincent T., BenMohamed, Lbachir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304367/
https://www.ncbi.nlm.nih.gov/pubmed/30619285
http://dx.doi.org/10.3389/fimmu.2018.02922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304367/
https://www.ncbi.nlm.nih.gov/pubmed/30619285
http://dx.doi.org/10.3389/fimmu.2018.02922

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