Cargando…

Blockade of LAG-3 Immune Checkpoint Combined With Therapeutic Vaccination Restore the Function of Tissue-Resident Anti-viral CD8(+) T Cells and Protect Against Recurrent Ocular Herpes Simplex Infection and Disease

Recurrent viral diseases often occur after the viruses evade the hosts' immune system, by inducing exhaustion of antiviral T cells. In the present study, we found that functionally exhausted herpes simplex virus type 1 (HSV-1) -specific CD8(+) T cells, with elevated expression of lymphocyte act...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roy, Soumyabrata, Coulon, Pierre-Grégoire, Srivastava, Ruchi, Vahed, Hawa, Kim, Grace J., Walia, Sager S., Yamada, Taikun, Fouladi, Mona A., Ly, Vincent T., BenMohamed, Lbachir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304367/ https://www.ncbi.nlm.nih.gov/pubmed/30619285 http://dx.doi.org/10.3389/fimmu.2018.02922

Ejemplares similares

Unique molecular signatures of antiviral memory CD8(+) T cells associated with asymptomatic recurrent ocular herpes
por: Prakash, Swayam, et al.
Publicado: (2020)

Combinatorial Herpes Simplex Vaccine Strategies: From Bedside to Bench and Back
por: Chentoufi, Aziz A., et al.
Publicado: (2022)

Mucosal Herpes Immunity and Immunopathology to Ocular and Genital Herpes Simplex Virus Infections
por: Chentoufi, Aziz Alami, et al.
Publicado: (2012)

Immunity to Ocular and Genital Herpes Simplex Viruses Infections
por: Chentoufi, Aziz Alami, et al.
Publicado: (2012)

High Frequencies of Phenotypically and Functionally Senescent and Exhausted CD56(+)CD57(+)PD-1(+) Natural Killer Cells, SARS-CoV-2-Specific Memory CD4(+) and CD8(+) T cells Associated with Severe Disease in Unvaccinated COVID-19 Patients
por: Srivastava, Ruchi, et al.
Publicado: (2022)

Healing of Ocular Herpetic Disease Following Treatment With an Engineered FGF-1 Is Associated With Increased Corneal Anti-Inflammatory M2 Macrophages
por: Dhanushkodi, Nisha R., et al.
Publicado: (2021)

High Frequencies of Antiviral Effector Memory T(EM) Cells and Memory B Cells Mobilized into Herpes Infected Vaginal Mucosa Associated With Protection Against Genital Herpes
por: Dhanushkodi, Nisha Rajeswari, et al.
Publicado: (2023)

Therapeutic Prime/Pull Vaccination of HSV-2 Infected Guinea Pigs with the Ribonucleotide Reductase 2 (RR2) Protein and CXCL11 Chemokine Boosts Antiviral Local Tissue-Resident and Effector Memory CD4(+) and CD8(+) T Cells and Protects Against Recurrent Genital Herpes
por: Quadiri, Afshana, et al.
Publicado: (2023)

Towards a Rational Design of an Asymptomatic Clinical Herpes Vaccine: The Old, the New, and the Unknown
por: Alami Chentoufi, Aziz, et al.
Publicado: (2012)

NLRP3, NLRP12, and IFI16 Inflammasomes Induction and Caspase-1 Activation Triggered by Virulent HSV-1 Strains Are Associated With Severe Corneal Inflammatory Herpetic Disease
por: Coulon, Pierre-Gregoire, et al.
Publicado: (2019)

Isolation, characterization and acyclovir susceptibility of herpes simplex virus isolates among immunocompromised patients
por: Nag, Soumyabrata, et al.
Publicado: (2021)

Seroprevalence of Herpes Simplex Virus Infection in HIV Coinfected Individuals in Eastern India with Risk Factor Analysis
por: Nag, Soumyabrata, et al.
Publicado: (2015)

Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections
por: Koganti, Raghuram, et al.
Publicado: (2019)

Programmed Cell Death-Dependent Host Defense in Ocular Herpes Simplex Virus Infection
por: Guo, Hongyan, et al.
Publicado: (2022)

INCIDENCE OF HERPES SIMPLEX VIRUS KERATITIS AND OTHER OCULAR DISEASE: GLOBAL REVIEW AND ESTIMATES
por: McCormick, Ian, et al.
Publicado: (2021)

Herpes Simplex and Pseudorabies Viruses
por: Hierholzer, Walter J.
Publicado: (1970)

Treatment of Herpes Simplex Encephalitis
por: Illis, L. S., et al.
Publicado: (1972)

Fulminating herpes simplex hepatitis
por: Ahmed, Raheel, et al.
Publicado: (2022)

Herpes Simplex Virus Infection Mimicking Bullous Disease in an Immunocompromised Patient
por: Lecluse, Anne L.Y., et al.
Publicado: (2010)

The interaction of Herpes Simplex Virus with murine lymphocytes. I. Mitogenic properties of herpes simplex virus
Publicado: (1977)

A novel bioluminescent herpes simplex virus 1 for in vivo monitoring of herpes simplex encephalitis
por: Uyar, Olus, et al.
Publicado: (2021)

Cross-Protection Induced by Highly Conserved Human B, CD4(+,) and CD8(+) T Cell Epitopes-Based Coronavirus Vaccine Against Severe Infection, Disease, and Death Caused by Multiple SARS-CoV-2 Variants of Concern
por: Prakash, Swayam, et al.
Publicado: (2023)

Herpes simplex encephalitis: A new type of “ICU-acquired infection”?
por: Hauw, Fabien, et al.
Publicado: (2020)

CXCL11 production in cerebrospinal fluid distinguishes herpes simplex meningitis from herpes simplex encephalitis
por: Lind, Liza, et al.
Publicado: (2017)

Herpesvirus Entry Mediator Binding Partners Mediate Immunopathogenesis of Ocular Herpes Simplex Virus 1 Infection
por: Park, Seo J., et al.
Publicado: (2020)

Zosteriform herpes simplex and herpes zoster: A clinical clue
por: Aithal, Sanath, et al.
Publicado: (2013)

Herpes simplex and herpes zoster viruses in COVID-19 patients
por: Katz, Joseph, et al.
Publicado: (2021)

Herpes Simplex Virus Infection in Pregnancy
por: Straface, Gianluca, et al.
Publicado: (2012)

Normocellular CSF in herpes simplex encephalitis
por: Saraya, Abhinbhen W., et al.
Publicado: (2016)

Autoimmune Post-Herpes Simplex Encephalitis
por: Chelse, Ana B., et al.
Publicado: (2016)

Photodynamic Inactivation of Herpes Simplex Viruses
por: Monjo, Andrea L.-A., et al.
Publicado: (2018)

Oncolytic herpes simplex virus and immunotherapy
por: Ma, Wenqing, et al.
Publicado: (2018)

Patient priorities in herpes simplex keratitis
por: Liu, Xiaoxuan, et al.
Publicado: (2019)

Palate herpes simplex virus infection
por: Mosaico, Giovanna, et al.
Publicado: (2020)

Herpes simplex infection of the eye: an introduction
por: Bagga, Bhupesh, et al.
Publicado: (2020)

Developments in Vaccination for Herpes Simplex Virus
por: Krishnan, Rohini, et al.
Publicado: (2021)

Pathogenesis and virulence of herpes simplex virus
por: Zhu, Shuyong, et al.
Publicado: (2021)

Ocular disease pattern induced by herpes simplex virus is genetically determined by a specific region of viral DNA
Publicado: (1982)

Advancement on Sustained Antiviral Ocular Drug Delivery for Herpes Simplex Virus Keratitis: Recent Update on Potential Investigation
por: Pandey, Manisha, et al.
Publicado: (2020)

Role of Innate Interferon Responses at the Ocular Surface in Herpes Simplex Virus-1-Induced Herpetic Stromal Keratitis
por: Ren, Jiayi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_abeufl3av1fl1cnisitp23naa9