Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK

BRAF is a cytoplasmic protein kinase, which activates the MEK-ERK signalling pathway. Deregulation of the pathway is associated with the presence of BRAF mutations in human cancer, the most common being (V600E)BRAF, although structural rearrangements, which remove N-terminal regulatory sequences, ha...

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Detalles Bibliográficos
Autores principales: Hey, Fiona, Andreadi, Catherine, Noble, Catherine, Patel, Bipin, Jin, Hong, Kamata, Tamihiro, Straatman, Kees, Luo, Jinli, Balmanno, Kathryn, Jones, David T.W., Collins, V. Peter, Cook, Simon J., Caunt, Christopher J., Pritchard, Catrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304467/
https://www.ncbi.nlm.nih.gov/pubmed/30603699
http://dx.doi.org/10.1016/j.heliyon.2018.e01065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304467/
https://www.ncbi.nlm.nih.gov/pubmed/30603699
http://dx.doi.org/10.1016/j.heliyon.2018.e01065

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