Amelioration of Lipopolysaccharide-Induced Acute Lung Injury in Rats by Na-H Exchanger-1 Inhibitor Amiloride Is Associated with Reversal of ERK Mitogen-Activated Protein Kinase

BACKGROUND: Na-H exchanger-1 (NHE-1) is expressed in the lung of rats. Accumulating evidence shows that Na-H exchangers are involved in inflammation. Amiloride, an inhibitor of NHE-1, inhibits the activation of macrophages and endothelial cells and reduces their production of cytokines. Since these...

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Detalles Bibliográficos
Autores principales: Zhang, Yan, He, Hao, Zhang, Boran, Chen, Qinghong, Yao, Shanglong, Gui, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304609/
https://www.ncbi.nlm.nih.gov/pubmed/30627552
http://dx.doi.org/10.1155/2018/3560234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304609/
https://www.ncbi.nlm.nih.gov/pubmed/30627552
http://dx.doi.org/10.1155/2018/3560234

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