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The Effect of Tobacco Smoking on Bone Mass: An Overview of Pathophysiologic Mechanisms

Recent evidence demonstrates that tobacco smoking causes an imbalance in bone turnover, leading to lower bone mass and making bone vulnerable to osteoporosis and fracture. Tobacco smoke influences bone mass indirectly through alteration of body weight, parathyroid hormone-vitamin D axis, adrenal hor...

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Autores principales: Al-Bashaireh, Ahmad M., Haddad, Linda G., Weaver, Michael, Chengguo, Xing, Kelly, Debra Lynch, Yoon, Saunjoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304634/
https://www.ncbi.nlm.nih.gov/pubmed/30631414
http://dx.doi.org/10.1155/2018/1206235
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author Al-Bashaireh, Ahmad M.
Haddad, Linda G.
Weaver, Michael
Chengguo, Xing
Kelly, Debra Lynch
Yoon, Saunjoo
author_facet Al-Bashaireh, Ahmad M.
Haddad, Linda G.
Weaver, Michael
Chengguo, Xing
Kelly, Debra Lynch
Yoon, Saunjoo
author_sort Al-Bashaireh, Ahmad M.
collection PubMed
description Recent evidence demonstrates that tobacco smoking causes an imbalance in bone turnover, leading to lower bone mass and making bone vulnerable to osteoporosis and fracture. Tobacco smoke influences bone mass indirectly through alteration of body weight, parathyroid hormone-vitamin D axis, adrenal hormones, sex hormones, and increased oxidative stress on bony tissues. Also, tobacco smoke influences bone mass through a direct effect on osteogenesis and angiogenesis of bone. A RANKL-RANK-OPG pathway is an essential regulatory pathway for bone metabolism and its importance lies in its interaction with most of the pathophysiologic mechanisms by which smoking influences bone mass. Both first- and secondhand smoke adversely affect bone mass; smoking cessation seems to reverse the effect of smoking and improve bone health. Recent advances in research on bone turnover markers could advance scientific knowledge regarding the mechanisms by which smoking may influence bone mass.
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spelling pubmed-63046342019-01-10 The Effect of Tobacco Smoking on Bone Mass: An Overview of Pathophysiologic Mechanisms Al-Bashaireh, Ahmad M. Haddad, Linda G. Weaver, Michael Chengguo, Xing Kelly, Debra Lynch Yoon, Saunjoo J Osteoporos Review Article Recent evidence demonstrates that tobacco smoking causes an imbalance in bone turnover, leading to lower bone mass and making bone vulnerable to osteoporosis and fracture. Tobacco smoke influences bone mass indirectly through alteration of body weight, parathyroid hormone-vitamin D axis, adrenal hormones, sex hormones, and increased oxidative stress on bony tissues. Also, tobacco smoke influences bone mass through a direct effect on osteogenesis and angiogenesis of bone. A RANKL-RANK-OPG pathway is an essential regulatory pathway for bone metabolism and its importance lies in its interaction with most of the pathophysiologic mechanisms by which smoking influences bone mass. Both first- and secondhand smoke adversely affect bone mass; smoking cessation seems to reverse the effect of smoking and improve bone health. Recent advances in research on bone turnover markers could advance scientific knowledge regarding the mechanisms by which smoking may influence bone mass. Hindawi 2018-12-02 /pmc/articles/PMC6304634/ /pubmed/30631414 http://dx.doi.org/10.1155/2018/1206235 Text en Copyright © 2018 Ahmad M. Al-Bashaireh et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Al-Bashaireh, Ahmad M.
Haddad, Linda G.
Weaver, Michael
Chengguo, Xing
Kelly, Debra Lynch
Yoon, Saunjoo
The Effect of Tobacco Smoking on Bone Mass: An Overview of Pathophysiologic Mechanisms
title The Effect of Tobacco Smoking on Bone Mass: An Overview of Pathophysiologic Mechanisms
title_full The Effect of Tobacco Smoking on Bone Mass: An Overview of Pathophysiologic Mechanisms
title_fullStr The Effect of Tobacco Smoking on Bone Mass: An Overview of Pathophysiologic Mechanisms
title_full_unstemmed The Effect of Tobacco Smoking on Bone Mass: An Overview of Pathophysiologic Mechanisms
title_short The Effect of Tobacco Smoking on Bone Mass: An Overview of Pathophysiologic Mechanisms
title_sort effect of tobacco smoking on bone mass: an overview of pathophysiologic mechanisms
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304634/
https://www.ncbi.nlm.nih.gov/pubmed/30631414
http://dx.doi.org/10.1155/2018/1206235
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