ALS mutations of FUS suppress protein translation and disrupt the regulation of nonsense-mediated decay

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by preferential motor neuron death. Approximately 15% of ALS cases are familial, and mutations in the fused in sarcoma (FUS) gene contribute to a subset of familial ALS cases. FUS is a multifunctional protein...

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Detalles Bibliográficos
Autores principales: Kamelgarn, Marisa, Chen, Jing, Kuang, Lisha, Jin, Huan, Kasarskis, Edward J., Zhu, Haining
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304956/
https://www.ncbi.nlm.nih.gov/pubmed/30455313
http://dx.doi.org/10.1073/pnas.1810413115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304956/
https://www.ncbi.nlm.nih.gov/pubmed/30455313
http://dx.doi.org/10.1073/pnas.1810413115

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