Cargando…
Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states
Protein kinases undergo large-scale structural changes that tightly regulate function and control recognition by small-molecule inhibitors. Methods for quantifying the conformational effects of inhibitors and linking them to an understanding of selectivity patterns have long been elusive. We have de...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304972/ https://www.ncbi.nlm.nih.gov/pubmed/30518564 http://dx.doi.org/10.1073/pnas.1811158115 |