Mycoplasma promotes malignant transformation in vivo, and its DnaK, a bacterial chaperone protein, has broad oncogenic properties

We isolated a strain of human mycoplasma that promotes lymphomagenesis in SCID mice, pointing to a p53-dependent mechanism similar to lymphomagenesis in uninfected p53(−/−) SCID mice. Additionally, mycoplasma infection in vitro reduces p53 activity. Immunoprecipitation of p53 in mycoplasma-infected...

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Detalles Bibliográficos
Autores principales: Zella, Davide, Curreli, Sabrina, Benedetti, Francesca, Krishnan, Selvi, Cocchi, Fiorenza, Latinovic, Olga S., Denaro, Frank, Romerio, Fabio, Djavani, Mahmoud, Charurat, Man E., Bryant, Joseph L., Tettelin, Hervé, Gallo, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304983/
https://www.ncbi.nlm.nih.gov/pubmed/30509983
http://dx.doi.org/10.1073/pnas.1815660115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304983/
https://www.ncbi.nlm.nih.gov/pubmed/30509983
http://dx.doi.org/10.1073/pnas.1815660115

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