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Mycoplasma promotes malignant transformation in vivo, and its DnaK, a bacterial chaperone protein, has broad oncogenic properties
We isolated a strain of human mycoplasma that promotes lymphomagenesis in SCID mice, pointing to a p53-dependent mechanism similar to lymphomagenesis in uninfected p53(−/−) SCID mice. Additionally, mycoplasma infection in vitro reduces p53 activity. Immunoprecipitation of p53 in mycoplasma-infected...
Autores principales: | Zella, Davide, Curreli, Sabrina, Benedetti, Francesca, Krishnan, Selvi, Cocchi, Fiorenza, Latinovic, Olga S., Denaro, Frank, Romerio, Fabio, Djavani, Mahmoud, Charurat, Man E., Bryant, Joseph L., Tettelin, Hervé, Gallo, Robert C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304983/ https://www.ncbi.nlm.nih.gov/pubmed/30509983 http://dx.doi.org/10.1073/pnas.1815660115 |
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