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Ablation of α(2)δ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo
The auxiliary α(2)δ calcium channel subunits play key roles in voltage-gated calcium channel function. Independent of this, α(2)δ-1 has also been suggested to be important for synaptogenesis. Using an epitope-tagged knockin mouse strategy, we examined the effect of α(2)δ-1 on Ca(V)2.2 localization i...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305000/ https://www.ncbi.nlm.nih.gov/pubmed/30487217 http://dx.doi.org/10.1073/pnas.1811212115 |