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Ablation of α(2)δ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo

The auxiliary α(2)δ calcium channel subunits play key roles in voltage-gated calcium channel function. Independent of this, α(2)δ-1 has also been suggested to be important for synaptogenesis. Using an epitope-tagged knockin mouse strategy, we examined the effect of α(2)δ-1 on Ca(V)2.2 localization i...

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Detalles Bibliográficos
Autores principales:	Nieto-Rostro, Manuela, Ramgoolam, Krishma, Pratt, Wendy S., Kulik, Akos, Dolphin, Annette C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2018
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305000/ https://www.ncbi.nlm.nih.gov/pubmed/30487217 http://dx.doi.org/10.1073/pnas.1811212115

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