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False positives in trans-eQTL and co-expression analyses arising from RNA-sequencing alignment errors

Sequence similarity among distinct genomic regions can lead to errors in alignment of short reads from next-generation sequencing. While this is well known, the downstream consequences of misalignment have not been fully characterized.  We assessed the potential for incorrect alignment of RNA-sequen...

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Detalles Bibliográficos
Autores principales: Saha, Ashis, Battle, Alexis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305209/
https://www.ncbi.nlm.nih.gov/pubmed/30613398
http://dx.doi.org/10.12688/f1000research.17145.2