HMGN1 and R848 Synergistically Activate Dendritic Cells Using Multiple Signaling Pathways

High mobility group nucleosome-binding protein 1 (HMGN1 or N1) is a Th1-polarizing alarmin, but alone is insufficient to induce antitumor immunity. We previously showed that combination of N1 and R848, a synthetic TLR7/8 agonist, synergistically activates dendritic cells (DCs) and induces therapeuti...

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Detalles Bibliográficos
Autores principales: Alam, Md Masud, Yang, De, Trivett, Anna, Meyer, Thomas J., Oppenheim, Joost J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305469/
https://www.ncbi.nlm.nih.gov/pubmed/30619338
http://dx.doi.org/10.3389/fimmu.2018.02982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305469/
https://www.ncbi.nlm.nih.gov/pubmed/30619338
http://dx.doi.org/10.3389/fimmu.2018.02982

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