Cargando…
Cellular Mechanisms of Sinus Node Dysfunction in Carriers of the SCN5A-E161K Mutation and Role of the H558R Polymorphism
Background: Carriers of the E161K mutation in the SCN5A gene, encoding the Na(V)1.5 pore-forming α-subunit of the ion channel carrying the fast sodium current (I(Na)), show sinus bradycardia and occasional exit block. Voltage clamp experiments in mammalian expression systems revealed a mutation-indu...
| Autor principal: | |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305593/ https://www.ncbi.nlm.nih.gov/pubmed/30618807 http://dx.doi.org/10.3389/fphys.2018.01795 |