Magnetic Force-Based Microfluidic Techniques for Cellular and Tissue Bioengineering

Live cell manipulation is an important biotechnological tool for cellular and tissue level bioengineering applications due to its capacity for guiding cells for separation, isolation, concentration, and patterning. Magnetic force-based cell manipulation methods offer several advantages, such as low...

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Autores principales: Yaman, Sena, Anil-Inevi, Muge, Ozcivici, Engin, Tekin, H. Cumhur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305723/
https://www.ncbi.nlm.nih.gov/pubmed/30619842
http://dx.doi.org/10.3389/fbioe.2018.00192
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author Yaman, Sena
Anil-Inevi, Muge
Ozcivici, Engin
Tekin, H. Cumhur
author_facet Yaman, Sena
Anil-Inevi, Muge
Ozcivici, Engin
Tekin, H. Cumhur
author_sort Yaman, Sena
collection PubMed
description Live cell manipulation is an important biotechnological tool for cellular and tissue level bioengineering applications due to its capacity for guiding cells for separation, isolation, concentration, and patterning. Magnetic force-based cell manipulation methods offer several advantages, such as low adverse effects on cell viability and low interference with the cellular environment. Furthermore, magnetic-based operations can be readily combined with microfluidic principles by precisely allowing control over the spatiotemporal distribution of physical and chemical factors for cell manipulation. In this review, we present recent applications of magnetic force-based cell manipulation in cellular and tissue bioengineering with an emphasis on applications with microfluidic components. Following an introduction of the theoretical background of magnetic manipulation, components of magnetic force-based cell manipulation systems are described. Thereafter, different applications, including separation of certain cell fractions, enrichment of rare cells, and guidance of cells into specific macro- or micro-arrangements to mimic natural cell organization and function, are explained. Finally, we discuss the current challenges and limitations of magnetic cell manipulation technologies in microfluidic devices with an outlook on future developments in the field.
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spelling pubmed-63057232019-01-07 Magnetic Force-Based Microfluidic Techniques for Cellular and Tissue Bioengineering Yaman, Sena Anil-Inevi, Muge Ozcivici, Engin Tekin, H. Cumhur Front Bioeng Biotechnol Bioengineering and Biotechnology Live cell manipulation is an important biotechnological tool for cellular and tissue level bioengineering applications due to its capacity for guiding cells for separation, isolation, concentration, and patterning. Magnetic force-based cell manipulation methods offer several advantages, such as low adverse effects on cell viability and low interference with the cellular environment. Furthermore, magnetic-based operations can be readily combined with microfluidic principles by precisely allowing control over the spatiotemporal distribution of physical and chemical factors for cell manipulation. In this review, we present recent applications of magnetic force-based cell manipulation in cellular and tissue bioengineering with an emphasis on applications with microfluidic components. Following an introduction of the theoretical background of magnetic manipulation, components of magnetic force-based cell manipulation systems are described. Thereafter, different applications, including separation of certain cell fractions, enrichment of rare cells, and guidance of cells into specific macro- or micro-arrangements to mimic natural cell organization and function, are explained. Finally, we discuss the current challenges and limitations of magnetic cell manipulation technologies in microfluidic devices with an outlook on future developments in the field. Frontiers Media S.A. 2018-12-19 /pmc/articles/PMC6305723/ /pubmed/30619842 http://dx.doi.org/10.3389/fbioe.2018.00192 Text en Copyright © 2018 Yaman, Anil-Inevi, Ozcivici and Tekin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Yaman, Sena
Anil-Inevi, Muge
Ozcivici, Engin
Tekin, H. Cumhur
Magnetic Force-Based Microfluidic Techniques for Cellular and Tissue Bioengineering
title Magnetic Force-Based Microfluidic Techniques for Cellular and Tissue Bioengineering
title_full Magnetic Force-Based Microfluidic Techniques for Cellular and Tissue Bioengineering
title_fullStr Magnetic Force-Based Microfluidic Techniques for Cellular and Tissue Bioengineering
title_full_unstemmed Magnetic Force-Based Microfluidic Techniques for Cellular and Tissue Bioengineering
title_short Magnetic Force-Based Microfluidic Techniques for Cellular and Tissue Bioengineering
title_sort magnetic force-based microfluidic techniques for cellular and tissue bioengineering
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305723/
https://www.ncbi.nlm.nih.gov/pubmed/30619842
http://dx.doi.org/10.3389/fbioe.2018.00192
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