Whole-Genome Sequencing Identifies a Novel Variation of WAS Gene Coordinating With Heterozygous Germline Mutation of APC to Enhance Hepatoblastoma Oncogenesis

Hepatoblastoma (HB), a leading primary hepatic malignancy in children, originates from primitive hepatic stem cells. This study aimed to uncover the genetic variants that are responsible for HB oncogenesis. One family, which includes the healthy parents, and two brothers affected by HB, was recruite...

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Detalles Bibliográficos
Autores principales: Zhang, Li, Jin, Yaqiong, Zheng, Kai, Wang, Huanmin, Yang, Shen, Lv, Chenkai, Han, Wei, Yu, Yongbo, Yang, Yeran, Geng, Di, Yang, Hui, Shi, Tieliu, Guo, Yongli, Ni, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305990/
https://www.ncbi.nlm.nih.gov/pubmed/30619485
http://dx.doi.org/10.3389/fgene.2018.00668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305990/
https://www.ncbi.nlm.nih.gov/pubmed/30619485
http://dx.doi.org/10.3389/fgene.2018.00668

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