Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in TP53-deficient cancer cells

BACKGROUND: The p73 protein is a tumor suppressor that shares structural and functional similarity with p53. p73 is expressed in two major isoforms; the TA isoform that interacts with p53 pathway, thus acting as tumor suppressor and the N-terminal truncated ΔN isoform that inhibits TAp73 and p53 and...

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Detalles Bibliográficos
Autores principales: Sznarkowska, Alicja, Kostecka, Anna, Kawiak, Anna, Acedo, Pilar, Lion, Mattia, Inga, Alberto, Zawacka-Pankau, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306007/
https://www.ncbi.nlm.nih.gov/pubmed/30603043
http://dx.doi.org/10.1186/s13008-018-0043-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306007/
https://www.ncbi.nlm.nih.gov/pubmed/30603043
http://dx.doi.org/10.1186/s13008-018-0043-3

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