Cargando…

Proteolytic cleavage of amyloid precursor protein by ADAM10 mediates proliferation and migration in breast cancer

BACKGROUND: Amyloid precursor protein (APP), best known for its association with Alzheimer disease, has recently been implicated in breast cancer progression. However, the precise mechanism involved remains unclear. Here, we investigated the role of APP proteolytic cleavage in breast cancer function...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tsang, Julia Y.S., Lee, Michelle A., Chan, Tsz-Hei, Li, Joshua, Ni, Yun-Bi, Shao, Yan, Chan, Siu-Ki, Cheungc, Sai-Yin, Lau, Kwok-Fai, Tse, Gary M.K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306343/ https://www.ncbi.nlm.nih.gov/pubmed/30470613 http://dx.doi.org/10.1016/j.ebiom.2018.11.012

Ejemplares similares

Determination of the Proteolytic Cleavage Sites of the Amyloid Precursor-Like Protein 2 by the Proteases ADAM10, BACE1 and γ-Secretase
por: Hogl, Sebastian, et al.
Publicado: (2011)

Pseudomonas aeruginosa Triggered Exosomal Release of ADAM10 Mediates Proteolytic Cleavage in Trans
por: Aljohmani, Ahmad, et al.
Publicado: (2022)

Cytoskeletal confinement of CX(3)CL1 limits its susceptibility to proteolytic cleavage by ADAM10
por: Wong, Harikesh S., et al.
Publicado: (2014)

The Emerging Role of Tetraspanins in the Proteolytic Processing of the Amyloid Precursor Protein
por: Seipold, Lisa, et al.
Publicado: (2016)

Scramblases as Regulators of Proteolytic ADAM Function
por: Reiss, Karina, et al.
Publicado: (2022)

Amyloid precursor protein and its interacting proteins in neurodevelopment
por: Chau, Dennis Dik-Long, et al.
Publicado: (2023)

Corrigendum: The Emerging Role of Tetraspanins in the Proteolytic Processing of the Amyloid Precursor Protein
por: Seipold, Lisa, et al.
Publicado: (2017)

Regulation of proteolytic cleavage of brain-derived neurotrophic factor precursor by antidepressants in human neuroblastoma cells
por: Lin, Pao-Yen
Publicado: (2015)

The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43
por: Hicks, David A., et al.
Publicado: (2020)

Proteolytic Cleavage of Receptor Tyrosine Kinases
por: Huang, Hao
Publicado: (2021)

Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems
por: Hunter, Sally, et al.
Publicado: (2012)

Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments
por: Wild, Klemens, et al.
Publicado: (2017)

FGFR1 is an adverse outcome indicator for luminal A breast cancers
por: Shi, Yu-Jie, et al.
Publicado: (2015)

Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing
por: Lee, Yat Shing, et al.
Publicado: (2017)

Dapagliflozin Inhibits Cell Adhesion to Collagen I and IV and Increases Ectodomain Proteolytic Cleavage of DDR1 by Increasing ADAM10 Activity
por: Okada, Junichi, et al.
Publicado: (2020)

Ex vivo analysis platforms for monitoring amyloid precursor protein cleavage
por: Kamikubo, Yuji, et al.
Publicado: (2023)

Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration
por: Bieri, Gregor, et al.
Publicado: (2018)

Proteolytic α-Synuclein Cleavage in Health and Disease
por: Bluhm, Alexandra, et al.
Publicado: (2021)

Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers
por: Jarosz-Griffiths, Heledd H., et al.
Publicado: (2019)

The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by α-secretase ADAM10
por: Hitschler, Lisa, et al.
Publicado: (2022)

Selectivity to amyloid-β precursor protein cleavage provides hope against Alzheimer's
por: Tomita, Taisuke, et al.
Publicado: (2011)

Proteolytic Cleavage of Apolipoprotein E in the Down Syndrome Brain
por: Day, Ryan J., et al.
Publicado: (2016)

Fungal gasdermin-like proteins are controlled by proteolytic cleavage
por: Clavé, Corinne, et al.
Publicado: (2022)

Galectin 3–binding protein suppresses amyloid-β production by modulating β-cleavage of amyloid precursor protein
por: Seki, Tsuneyoshi, et al.
Publicado: (2020)

Pro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pH
por: Sidera, Christina, et al.
Publicado: (2002)

Structural Characterization of the Amyloid Precursor Protein Transmembrane Domain and Its γ-Cleavage Site
por: Itkin, Anna, et al.
Publicado: (2017)

Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy
por: Cavieres, Viviana A., et al.
Publicado: (2015)

Proteolytic cleavage of p53 mutants in response to mismatched DNA
por: Mee, T, et al.
Publicado: (1999)

Correct proteolytic cleavage is required for the cell adhesive function of uvomorulin
Publicado: (1990)

Requirements for Efficient Proteolytic Cleavage of Prelamin A by ZMPSTE24
por: Barrowman, Jemima, et al.
Publicado: (2012)

Cleavage of HMGB1 by Proteolytic Enzymes Associated with Inflammatory Conditions
por: Sowinska, Agnieszka, et al.
Publicado: (2020)

Is BECN1 a Target Gene of Chromosome 17q21 Alteration in Breast Cancer?
por: Tsang, Julia Y.S., et al.
Publicado: (2015)

Phosphorylation of FE65 Ser(610) by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing
por: Chow, Wan Ning Vanessa, et al.
Publicado: (2015)

The Clinical Value of PELP1 for Breast Cancer: A Comparison with Multiple Cancers and Analysis in Breast Cancer Subtypes
por: Wang, Xingen, et al.
Publicado: (2019)

Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals
Publicado: (1995)

Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17
por: Riethmueller, Steffen, et al.
Publicado: (2016)

Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation
por: Jin, Chen, et al.
Publicado: (2022)

CD19 regulates ADAM28‐mediated Notch2 cleavage to control the differentiation of marginal zone precursors to MZ B cells
por: Zhang, Yu, et al.
Publicado: (2017)

γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)
por: Lessard, Christian B., et al.
Publicado: (2015)

Doublecortin-like kinase 1 expression associates with breast cancer with neuroendocrine differentiation
por: Liu, Yu-Hong, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_pklmhbcigfil2crane0vg2i4kh