The development of a GPR44 targeting radioligand [(11)C]AZ12204657 for in vivo assessment of beta cell mass

BACKGROUND: The G-protein-coupled receptor 44 (GPR44) is a beta cell-restricted target that may serve as a marker for beta cell mass (BCM) given the development of a suitable PET ligand. METHODS: The binding characteristics of the selected candidate, AZ12204657, at human GPR44 were determined using...

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Detalles Bibliográficos
Autores principales: Jahan, Mahabuba, Johnström, Peter, Selvaraju, Ram K., Svedberg, Marie, Winzell, Maria Sörhede, Bernström, Jenny, Kingston, Lee, Schou, Magnus, Jia, Zhisheng, Skrtic, Stanko, Johansson, Lars, Korsgren, Olle, Farde, Lars, Halldin, Christer, Eriksson, Olof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306373/
https://www.ncbi.nlm.nih.gov/pubmed/30588560
http://dx.doi.org/10.1186/s13550-018-0465-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306373/
https://www.ncbi.nlm.nih.gov/pubmed/30588560
http://dx.doi.org/10.1186/s13550-018-0465-6

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