An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFRα Induces Anti-tumor Effects through STAT3 and p53 in Glioblastoma

Human glioblastoma (GBM) is the most aggressive malignancy of the CNS, with less than 5% survival. Despite great efforts to find effective therapeutics, current options remain very limited. To develop a targeted cancer therapeutic, we selected RNA aptamers against platelet-derived growth factor rece...

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Detalles Bibliográficos
Autores principales: Yoon, Sorah, Wu, Xiwei, Armstrong, Brian, Habib, Nagy, Rossi, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307106/
https://www.ncbi.nlm.nih.gov/pubmed/30594071
http://dx.doi.org/10.1016/j.omtn.2018.11.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307106/
https://www.ncbi.nlm.nih.gov/pubmed/30594071
http://dx.doi.org/10.1016/j.omtn.2018.11.012

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