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Lifestyle modifications: coordinating the tRNA epitranscriptome with codon bias to adapt translation during stress responses
Cells adapt to stress by altering gene expression at multiple levels. Here, we propose a new mechanism regulating stress-dependent gene expression at the level of translation, with coordinated interplay between the tRNA epitranscriptome and biased codon usage in families of stress-response genes. In...
Autores principales: | Chan, Cheryl, Pham, Phuong, Dedon, Peter C., Begley, Thomas J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307160/ https://www.ncbi.nlm.nih.gov/pubmed/30587213 http://dx.doi.org/10.1186/s13059-018-1611-1 |
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