Enhancing the efficiency of the Pichia pastoris AOX1 promoter via the synthetic positive feedback circuit of transcription factor Mxr1

BACKGROUND: The methanol-regulated AOX1 promoter (P(AOX1)) is the most widely used promoter in the production of recombinant proteins in the methylotrophic yeast Pichia pastoris. However, as the tight regulation and methanol dependence of P(AOX1) restricts its application, it is necessary to develop...

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Detalles Bibliográficos
Autores principales: Chang, Ching-Hsiang, Hsiung, Hao-An, Hong, Kai-Lin, Huang, Ching-Tsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307218/
https://www.ncbi.nlm.nih.gov/pubmed/30587177
http://dx.doi.org/10.1186/s12896-018-0492-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307218/
https://www.ncbi.nlm.nih.gov/pubmed/30587177
http://dx.doi.org/10.1186/s12896-018-0492-4

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