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Enhancing the efficiency of the Pichia pastoris AOX1 promoter via the synthetic positive feedback circuit of transcription factor Mxr1
BACKGROUND: The methanol-regulated AOX1 promoter (P(AOX1)) is the most widely used promoter in the production of recombinant proteins in the methylotrophic yeast Pichia pastoris. However, as the tight regulation and methanol dependence of P(AOX1) restricts its application, it is necessary to develop...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307218/ https://www.ncbi.nlm.nih.gov/pubmed/30587177 http://dx.doi.org/10.1186/s12896-018-0492-4 |