Challenges recruiting to a proof-of-concept pharmaceutical trial for a rare disease: the trigeminal neuralgia experience

BACKGROUND: This study aimed to describe recruitment challenges encountered during a phase IIa study of vixotrigine, a state and use-dependent Nav1.7 channel blocker, in individuals with trigeminal neuralgia. METHODS: This was an international, multicenter, placebo-controlled, randomized withdrawal...

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Detalles Bibliográficos
Autores principales: Zakrzewska, Joanna M., Palmer, Joanne, Bendtsen, Lars, Di Stefano, Giulia, Ettlin, Dominik A., Maarbjerg, Stine, Obermann, Mark, Morisset, Valerie, Steiner, Deb, Tate, Simon, Cruccu, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307274/
https://www.ncbi.nlm.nih.gov/pubmed/30587219
http://dx.doi.org/10.1186/s13063-018-3045-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307274/
https://www.ncbi.nlm.nih.gov/pubmed/30587219
http://dx.doi.org/10.1186/s13063-018-3045-1

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