Genetic Alphabet Expansion Provides Versatile Specificities and Activities of Unnatural-Base DNA Aptamers Targeting Cancer Cells

The potential of genetic alphabet expansion technologies using artificial extra base pairs (unnatural base pairs) has been rapidly expanding and increasing. We present that the hydrophobic unnatural base, 7-(2-thienyl)imidazo[4,5-b]pyridine (Ds), which acts as a fifth letter in a DNA library, provid...

Descripción completa

Detalles Bibliográficos
Autores principales: Futami, Kazunobu, Kimoto, Michiko, Lim, Yun Wei Shermane, Hirao, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307347/
https://www.ncbi.nlm.nih.gov/pubmed/30594072
http://dx.doi.org/10.1016/j.omtn.2018.11.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307347/
https://www.ncbi.nlm.nih.gov/pubmed/30594072
http://dx.doi.org/10.1016/j.omtn.2018.11.011

Ejemplares similares