Metformin attenuates the effect of Staphylococcus aureus on airway tight junctions by increasing PKCζ‐mediated phosphorylation of occludin

Airway epithelial tight junction (TJ) proteins form a resistive barrier to the external environment, however, during respiratory bacterial infection TJs become disrupted compromising barrier function. This promotes glucose flux/accumulation into the lumen which acts as a nutrient source for bacteria...

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Detalles Bibliográficos
Autores principales: Kalsi, Kameljit K., Garnett, James P., Patkee, Wishwanath, Weekes, Alexina, Dockrell, Mark E., Baker, Emma H., Baines, Deborah L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307806/
https://www.ncbi.nlm.nih.gov/pubmed/30450773
http://dx.doi.org/10.1111/jcmm.13929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307806/
https://www.ncbi.nlm.nih.gov/pubmed/30450773
http://dx.doi.org/10.1111/jcmm.13929

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